| Dosing Equivalency Information | Dosing Equivalency Information | ||||||||||||||||
| ACE Inhibitor Dosing | Angiotensin II Receptor Blocking Agent Dosing | ||||||||||||||||
| Drug | Comparable dose based on therapeutic interchange studies, comparative clinical studies, and manufacturer's recommended dosing for hypertension | Drug | Comparable dose based on therapeutic interchange studies, comparative clinical studies, and manufacturer's recommended dosing for hypertension | ||||||||||||||
| Benazepril (Lotensin) | 5mg daily | 10mg daily | 20 mg daily or 10mg twice daily | 40mg daily or 20mg twice daily | 80mg daily | ||||||||||||
| Candesartan (Atacand) | 4mg daily | 8mg daily or 4mg twice daily | 8mg daily or 4mg twice daily - 16mg daily or 8mg twice daily | 32mg daily or 16mg twice daily | |||||||||||||
| Captopril (Capoten) | 25mg twice daily or three times daily | 50mg twice daily | 100mg twice daily | 200mg twice daily | |||||||||||||
| Enalapril (Vasotec) | 2.5mg daily | 5mg daily | 10mg daily or 5mg twice daily | 20mg daily or 10mg twice daily | 40mg daily or 20mg twice daily | Eprosartan (Teveten) | 400mg daily | 600mg daily | 800mg daily or 400mg twice daily | ||||||||
| Fosinopril (Monopril) | 10mg daily or 5mg twice daily | 20mg daily or 10mg twice daily | 40mg daily or 20mg twice daily | 80mg daily or 40mg twice daily | Irbesartan (Avapro) | 75mg daily | 150mg daily | 300mg daily | |||||||||
| Losartan (Cozaar) | 25mg daily | 50mg daily or 25mg twice daily | 100mg daily or 50mg twice daily | ||||||||||||||
| Lisinopril (Prinivil, Zestril) | 5mg daily | 10mg daily or 5mg twice daily | 20mg daily or 10mg twice daily | 40mg daily or 20mg twice daily | 80mg daily or 40mg twice daily | ||||||||||||
| Olmesartan (Benicar) | 5mg daily | 10mg daily | 20mg daily | 40mg daily | |||||||||||||
| Moexipril (Univasc) | 3.75mg daily | 7.5mg daily or 3.75mg twice daily | 15mg daily or 7.5mg twice daily | 30mg daily or 15mg twice daily | 60mg daily or 30mg twice daily | ||||||||||||
| Telmisartan (Micardis) | 20mg daily | 40mg daily | 80mg daily | ||||||||||||||
| Perindopril (Aceon) | 2mg daily | 4mg daily or 2mg twice daily | 8mg daily or 4mg twice daily | 16mg daily or 8mg twice daily | Valsartan (Diovan) | 40mg daily or 20mg twice daily | 80mg daily or 40mg twice daily | 160mg daily | 320mg daily | ||||||||
| Quinapril (Accupril) | 5mg daily | 10mg daily or 20mg daily | 20mg daily or 10mg twice daily | 40mg daily or 20mg twice daily | 80mg daily or 40mg twice daily | ||||||||||||
| Ramipril (Altace) | 1.25mg daily | 2.5mg daily or 1.25mg twice daily | 5mg daily or 2.5mg twice daily | 10mg daily or 5mg twice daily | 20mg daily or 10mg twice daily | Proton Pump Inhibitor Dosing | |||||||||||
| Drug | Usual Dosage | H. Pylori Dosing | |||||||||||||||
| Esomeprazole (Nexium) | 40mg daily | 40mg daily | |||||||||||||||
| Trandolapril (Mavik) | 0.5mg daily | 1mg daily | 2mg daily | 4mg daily | 4mg twice daily | ||||||||||||
| Lansoprazole (Prevacid) | 30mg daily | 30mg twice daily | |||||||||||||||
| Omeprazole (Prilosec) | 20mg daily | 20-40mg daily | |||||||||||||||
| Pantoprazole (Protonix) | 40mg daily | 40mg IV twice daily | |||||||||||||||
| Rabeprazole (Aciphex) | 20mg daily | 20mg twice daily | |||||||||||||||
| H2 Antagonist Dosing | |||||||||||||||||
| Drug | Dosing | ||||||||||||||||
| Cimetidine (Tagamet) | 400mg daily | 800mg daily | |||||||||||||||
| Famotidine (Pepcid) | 20mg daily | 40mg daily | |||||||||||||||
| Nizatidine (Axid) | 150mg daily | 300mg daily | |||||||||||||||
| Ranitidine (Zantac) | 150mg daily | 300mg daily | |||||||||||||||
| Dosing Equivalency Information | |||||||||||||||||
| HMG-CoA Reductase Inhibitor Dosing | |||||||||||||||||
| Drug | Daily adult dose providing similar average LDL lowering (by percentage) | ||||||||||||||||
| Atorvastatin (Lipitor) | 10mg (35-39%) | 20mg (43%) | 40mg (50%) | 80mg (60%) | |||||||||||||
| Fluvastatin (Lescol, Lescol XL) | 20mg (22%) | 40mg (25%) | 80mg (35% as XL) | ||||||||||||||
| Lovastatin (Mevacor) | 10mg (21%) | 20mg (24-27%) | 40mg (30-31%) to 80mg (40-42%) as 40mg twice daily | 80mg (40-42%) as 40mg twice daily | |||||||||||||
| Pravastatin (Pravachol) | 10mg (22%) | 20mg (32%) | 40mg (34%) to 80mg (37%) | 80mg (37%) | |||||||||||||
| Rosuvastatin (Crestor) | 5mg (45%) | 10mg (46-52%) to 20mg (47-55%) | 20mg (47-55%) to 40mg (55-63%) | ||||||||||||||
| Simvastatin (Zocor) | 5mg (26%) | 5mg (26%) to 10mg (30%) | 20mg (38%) | 40mg (29-41%) | 80mg (36-47%) | ||||||||||||
| Simvastatin/Ezetimibe (Vytorin) | 10/10mg (45%) | 10/20mg (52%) to 10/40mg (55%) | 10/40mg (55%) to 10/80mg (60%) | ||||||||||||||
| Coreg/Coreg CR Dosing | Hytrin to Cardura Conversion | ||||||||||||||||
| Coreg Dose | Coreg CR Dose | Cardura dose = Hytrin dose x 0.8 (rounded to nearest whole number) | |||||||||||||||
| 3.125mg twice daily | 10mg daily | ||||||||||||||||
| 6.25mg twice daily | 20mg daily | Conversion of IV Cardizem to oral Cardizem | |||||||||||||||
| Oral dose (mg/day) is approximately equal to [rate (mg/hr) X 3 + 3] X 10 | |||||||||||||||||
| 12.5mg twice daily | 40mg daily | ||||||||||||||||
| 25mg twice daily | 80mg daily | ||||||||||||||||